Zambo went from Stade de Reims to Marseille in 2015. On September 17, 2015, in the UEFA Europa League matchup against FC Groningen, he made his first team debut. He made his Ligue 1 debut against Lyon three days later. He participated in the UEFA Europa League Final on May 16, 2018, which Atlético Madrid won against Marseille at the Parc Olympique Lyonnais in Décines-Charpieu, Lyon, France.

He was moved from Marseille to Fulham in August 2018 and then loaned to Villarreal in July 2019 as a result of Fulham’s relegation from the Premier League. Anguissa signed a new three-year deal with the Championship side on August 31, 2021, and spent the 2021–22 season on loan at Napoli before making his Villarreal debut on August 17 in a 4–4 home draw against Granada CF.

Fulham sold Napoli the rights to Anguissa on May 26, 2022. He scored his first Champions League goal on September 7 in a 4-1 victory against Liverpool. His first Serie A goal came on October 1 when he scored twice in a 3-1 victory against Torino. On March 24, 2017, Zambo Anguissa made his debut for the Cameroon national team against Tunisia in a 1-0 friendly victory.

Zambo Anguissa’s annual salary is 2.8 million Euros (2.4 million Pounds).

Anguissa is active on Instagram. He has 265K+ followers on Instagram.